Abstract
Several hundred compounds which had undergone multiple anti-inflammatory testing provided the basis for comparing three in vitro and four in vivo models. Chi-square analysis for concordance of test results showed highly significant associations among the following: albumin denaturation, sulfhydryl-disulfide inter-change, aldehyde binding, broncho-constriction by bradykinin, and acute knee joint synovitis. Results of paw edema or cotton pellet granuloma tests were apparently independent of other test results.
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