Correlation between Immature Platelet Fraction and Platelet Aggregation in Type 2 Diabetes Mellitus with Cardiovascular Complications

Abstract

Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia that occurs due to abnormalities in insulin secretion, insulin action or both. Diabetes is a risk factor for cardiovascular disease and atherothrombosis is a common complication of diabetes. There are several markers that can be used to see and monitor changes in the thrombosis and coagulation processes in DM patients, including the platelet index, platelet aggregation and D-dimer. To determine the correlation between immature platelet fraction with platelet aggregation in type 2 diabetes mellitus with cardiovascular complications. This study used a cross-sectional design. A total of 30 people with type 2 diabetes mellitus with cardiovascular complications will be tested for IPF and Platelet aggregation. Of the 30 patients, the mean IPF was 5.83 ± 1.55 %. From the analysis of Correlation found a significant relationship between the value of IPF with Platelet aggregation on ADP 5 μM and ADP 10 μM (r = 0.68; p <0.05), (r = 0.73; p <0.05) in type 2 DM patients with cardiovascular complications. In type-2 diabetes mellitus, there is a decrease in platelet life time and increased platelet turnover resulting immature platelets that are more reactive, where it will be easier for atherothrombosis. Platelet aggregation is a process where platelets adhere to each other at the site of vascular injury, which serves for the formation of a hemostatic plug and thrombosis. There is a significant correlation between the value of IPF with platelet aggregation in patients with type 2 diabetes with cardiovascular complications. Keywords: IPF, Platelet Aggregation, Type-2 DM.