Abstract
The development of obesity and prediabetes under conditions of long-term consumption of fructose solution in ratsVictoria Konopelnyuk, Alona Yurchenko, Taras Karpovets, Ludmila Ostapchenko
Highlights
The incidence of depressive or anxiety disorders is up to 60%–80% higher in patients with type 2 diabetes mellitus (T2DM) than in the healthy population
This study aimed to explore the effectiveness of resveratrol (RSV) to counteract the neuro-complications accompanying high fat, high fructose (HFHF) diet experimentally induced-Insulin resistance (IR) in rats
On biochemical level; neurocomplications were assessed by measuring brain levels of monoamines and their metabolites as well as the levels of 8-hydroxyguanosine (8-OHDG), tumor necrosis factor-α (TNF-α), malondialdehyde (MDA), reduced and oxidized glutathione (GSH and GSSG) and nitric oxide (NOx)
Summary
The incidence of depressive or anxiety disorders is up to 60%–80% higher in patients with type 2 diabetes mellitus (T2DM) than in the healthy population. This could be partially explained by the fact that one of the key precursors of T2DM is the presence of an insulin-resistant state, and previously it was demonstrated that one of the major neurodegenerative disorders that comorbid with insulin resistance (IR) was depression (Kahl et al, 2015; Li et al, 2013; Ryan et al, 2012). Chronic IR has adverse consequences on the functional integrity of the CNS, including reduced receptor responsiveness and inhibition of downstream signaling (Arnold et al, 2014)
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