Correlation between anxiety, depression, and social stress in young patients with thoracolumbar spine fractures.

Objectives Hidradenitis suppurativa (HS) causes pain, discharge, odor, and scarring, potentially worsening sleep quality and psychological health. This study evaluated sleep, mood, and quality of life in HS patients compared to healthy controls, considering disease severity. We hypothesized that increased HS severity significantly impairs these outcomes. Methods This case-control study involved 55 HS patients from a university hospital and 55 healthy controls. Participants completed the Dermatology Life Quality Index (DLQI), Pittsburgh Sleep Quality Index (PSQI), and Hospital Anxiety and Depression Scale (HADS). HS severity was assessed using the Hurley staging system, and pain was measured with the Visual Analog Scale (VAS). Results HS patients had significantly higher anxiety, depression, DLQI, and PSQI scores than controls (p < 0.001). Depression scores correlated with Hurley stage (p = 0.041), but anxiety, DLQI, and PSQI scores did not (p > 0.05). VAS pain scores over the past week correlated with anxiety (p = 0.005), depression (p = 0.020), and DLQI scores (p < 0.001). DLQI scores positively correlated with depression, anxiety, and PSQI scores (p < 0.001, p < 0.001, p = 0.004, respectively). Depression scores correlated with anxiety and PSQI scores (p < 0.001 for both). Anxiety and PSQI scores also showed a positive correlation (p < 0.001). Conclusion HS is associated with poorer mood, sleep quality, and quality of life compared to healthy controls.

This study aimed to investigate anxiety, sleep quality, and their relationship with inflammation in patients with Takayasu’s arteritis (TA). Twenty-four patients diagnosed with TA and sex and age matched healthy controls were enrolled in the study. The quality of sleep was evaluated by Pittsburgh sleep quality index (PSQI), and anxiety were assessed by The Spielberger State-Trait Anxiety Inventory and Hamilton Anxiety Rating Scale. The disease activity was evaluated with sedimentation and C-reactive protein (CRP). The levels of anxiety and overall PSQI scores were significantly higher in TA than in healthy controls. Sleep disturbance was identified in half of the TA patients. The presence of systemic findings, CRP, and all subscale items of the Hamilton Anxiety Rating Scale and Spielberger State-Trait Anxiety Inventory were found to be higher in TA patients with poor sleepers compared to good sleepers. There was a significant correlation between all components of PSQI and anxiety scores. The present study has demonstrated higher anxiety scores and poor sleep quality among patients in TA compared with healthy controls. TA patients with systemic findings and high inflammation should be evaluated for poor sleep quality. Also, remission in disease activity may be associated with better sleep and less anxiety scores.

Objective To investigate the mental health status and sleep quality in elderly inpatients, and probe into the relationship between them. Methods A total of 300 elderly inpatients were selected from the Fourth Affiliated Hospital of Harbin Medical University from October 2005 to October 2007. Pittsburgh sleep quality index (PSQI) was used to assess the sleep quality, and Pittsburgh sleep quality index more than 8 was used as the judging standard of sleep disorder. The 300 patients were divided into the group of PSQI less than 5 (n = 70), the group of PSQI from 5 to 8 (n = 80), and the group of PSQI more than 8 (n = 146) according to their PSQI index. The symptom checklist 90 (SCL-90) was used to assess the influence of mental status. The objective and significance were explained to the patients before the test. The patients were asked to finish the questionnaires within 1 to 2 hours independently. The analysis of variance (ANOVA) was made to compare the means of scores for SCL-90, and correlation analysis based on Spearman was used to make the correlation test between the mental health status and sleep quality. Results According to the intention, all the 300 patients were analyzed in the result.① The scores of somatization, compulsion, depression, anxiety and psychoticism and the total score in the group of PSQI more than 8 were significantly higher than those in the groups of PSQI from 5 to 8 and less than 4. The higher the score of PSQI was, the higher the score of factors and the total score of SCL-90 were. ② The scores of somatization, compulsion, depression, anxiety and psychoticism and the total score were in a highly positive correlation with the sleep quality, wherein the scores of others, somatization and compulsion were in a significantly positive correlation with the scores of sleep, time for falling asleep, time of sleep and efficiency of sleep. The scores of depression and anxiety and the total score of SCL-90 were in a highly positive correlation with the score of efficiency of sleep. Conclusions The poorer the sleep quality in eider inpatients is, the higher the scores of depression and anxiety are, so they axe in a remarkable positive correlation. The poor sleep quality causes the emotional disorder such as depression and anxiety. Our results indicate that sleeplessness is not only a kind of physical order, but also a kind of mental order. Key words: Sleep quality; Mental status; Age; Relativity

Objective To evaluate the efficacy of anterior surgery and posterior surgery on thoracolumbar fractures complicated by spinal cord injury. Methods A total of 196 patients with thoracolumbar spine fractures complicated by spinal cord injury were enrolled and were divided into anterior operation group (n=98) and posterior operation group (n=98) according to the random number table method. The patients were examined by magnetic resonance imaging (MRI), computed tomography (CT) and X-ray, to thoroughly assess the condition of patient’s nerve injury and the degree of thoracolumbar fracture. The Cobb’s angle, the anterior height ratio of injured vertebrae, the Japanese Orthopaedic Association (JOA) score of lumbar and the JOA treatment index were compared between the two groups. Results Twelve and 24 months after operation, the ratio of anterior height of injured vertebrae in anterior operation group was significantly higher than that in posterior operation group (t=2.347, P=0.020; t=3.203, P=0.002); the Cobb angle in anterior operation group was significantly lower than that in posterior operation group (t=3.729, P<0.001; t=12.885, P<0.001). Compared with the posterior operation group, the JOA score (t=17.566, P<0.001) and JOA improvement index (t=19.240, P<0.001) were significantly improved in anterior operation group. Conclusions For patients with thoracolumbar fractures, the posterior operation has advantages of better short-term effects, low incidence of complications and simple operation. Compared with the posterior operation, the anterior operation has better fixation location which is conductive to recovery of spinal function, can decompress more completely, and has better effects. Key words: Thoracolumbar fracture; Anterior and posterior operation; Efficacy

Background &amp; Objectives: Thoraco-lumbar fracture is one of the common problems in spinal injury patients. It’s early management can prevent complication after injury and can improve neurological function. The treatment plan of unstable fracture is controversial. Methods: The study was carried out at the department of neurosurgery, Bangabandhu Sheikh Mujib Medical University from June 2010 to July 2011 among the patients admitted with thoraco-lumbar spine fracture. Results: A total number of 15 patients with thoracolumbar spine fracture were included in the study. Among the 15 patients, 13(86.66%) were male. The highest number of patients were in age group of 1-20(40%) and 21-40(40%) years. The commonest cause of Thoraco-lumbar spine injuries were fall from height which was 8(53.33%) in number. The commonest site of injury was L1 fracture in 4(60%) patients. It was documented that bladder dysfunction and lower limb weakness were the commonest sign. It was evident that, 10(66.70%) and 4(26.66%) of the patients were partially and completely improved after surgery respectively and 3(10%) of patients had wound infection. Conclusion: Thoraco-lumbar spine fracture with incomplete injury, early surgery can improve many of the patient’s life. DOI: http://dx.doi.org/10.3329/bjn.v28i2.17181 Bangladesh Journal of Neuroscience 2012; Vol. 28 (2): 102-107

Functional dyspepsia (FD) is one of the most common reasons for medical visits. Patients with FD incur large direct and indirect expenditures and may have significant financial burdens that affect quality of life. Our study aimed to assess the effectiveness of meditation as an adjuvant to the standard treatment in individuals diagnosed with FD. This will explore more cost-effective therapeutic management in diseases like FD, which is believed to be related to the gut-brain axis. Meditation is a nonpharmacological therapy, safer and economical, and its adjuvant use can minimize or avoid the adverse effects of long-term use of proton pump inhibitors (PPI) and tricyclic antidepressants (TCA). We wanted to comprehensively assess the role of meditation as an adjuvant therapy in patients with FD and compare it with the control arm receiving standard treatment alone. The primary objective was the change in gastrointestinal quality of life index (GIQLI) score, and the secondary objective was to assess the changes in the hospital anxiety and depression scale (HADS) score and Pittsburgh sleep quality index (PSQI) score before and after the intervention. Patients fulfilling the inclusion criteria were divided equally into two arms (experimental and control groups). The experimental group received standard treatment for dyspepsia (PPI, domperidone, TCAs) and Vaishvanara Agni meditation (VAM), while the control group received standard treatment alone. Both groups were compared at weeks 0, 4, and 8 in terms of change in GIQLI score, HADS (HADS-A and HADS-D score), and PSQI score. Our study showed that both groups experienced significant changes in GIQLI, HADS-A, HADS-D, and PSQI scores at 4 and 8 weeks when compared with the baseline time point. However, when both groups were directly compared, it was observed that the experimental group exhibited notable variations in the GIQLI score after 8 weeks, the HADS-D score after 8 weeks, and the PSQI score after 4 weeks when contrasted with the control group. These differences were found to be statistically significant. FD does not have an identified structural or biochemical cause, making it a functional gastrointestinal (GI) disorder that requires a tailored treatment approach. Our pilot randomized controlled trial (RCT) investigated the impact of meditation as adjuvant therapy for FD, revealing improvements in GI health, mental well-being, and sleep quality compared to standard treatment alone. The study recommends incorporating meditation into the management of FD and similar conditions, highlighting its holistic nature that addresses not only specific symptoms but also overall well-being. This study pioneers the examination of meditation as a complementary approach for FD, offering promising results in improving GIQLI, HADS, and PSQI scores and thus adding value to preexisting literature.

Purpose To explore the correlations between sleep quality and depression and anxiety in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A total of 131 AECOPD patients treated at No.6th People's Hospital affiliated to Shanghai Jiao Tong University School from January 2018 to December 2020 were selected and divided into the classes I (n = 30), II (n = 23), III (n = 37), and IV (n = 41) based on the severity of AECOPD. The Pittsburgh sleep quality index (PSQI) and the hospital anxiety and depression scale (HADS) were employed to assess the quality of sleep and anxiety/depression in AECOPD patients. The Pearson correlation analysis explored the associations between PSQI score and HADS anxiety/depression score. Binary logistic regression was utilized to determine risk factors for anxiety/depression in AECOPD patients. Results The PSQI score, HADS anxiety score, and HADS depression score in patients with AECOPD class III and class IV were significantly higher than those of classes I and II. The severe anxiety and depression ratio were significantly different among patients with classes I–IV AECOPD. The severity of AECOPD was significantly correlated with the PSQI score (r = 0.51, P < 0.001), HADS anxiety score (r = 0.66, P < 0.001), and HADS anxiety score (r = 0.65, P < 0.001). Binary logistic regression analysis showed that the COPD duration, the severity of AECOPD, and PSQI score were the risk factors for anxiety and depression in patients with AECOPD. Conclusions Poor sleep quality, anxiety, and depression are common in patients with AECOPD. Improvement of sleep quality may help to alleviate anxiety and depression in AECOPD patients.

This study aims to analyze the risk factors for acute pain after percutaneous vertebroplasty in patients with thoracolumbar spine fracture and create a predictive model for validation. Clinical data of thoracolumbar spine fracture patients admitted to our hospital from January 2023 to December 2024 were retrospectively collected, and the visual analog score was used to assess the pain within 48 hours after the operation, and a visual analog score of >3 was defined as acute pain. Independent risk factors were screened by univariate and multivariate logistic regression analyses, and the model was visualized using a nomogram. The performance of the model was assessed by calculating the area under the curve from the receiver operating characteristic curve, and the model fit was verified using the Hosmer–Lemeshow goodness-of-fit test. To improve the reliability of the validation results, Bootstrap combined with 10-fold cross-validation was used for internal validation, and calibration curve and decision curve analyses were applied to assess the clinical utility of the model. Two hundred ninety-four patients were included, of which 186 (63.27%) experienced acute pain after surgery. Univariate and multifactorial logistic regression analyses showed that 5 independent risk factors were associated with acute postoperative pain: body mass index > 24 kg/m2 (odds ratio [OR], 1.834; 95% confidence interval [CI], 1.230–4.324), number of fractured vertebra > 1 (OR, 3.902; 95% CI. 1.873–9.423), unsatisfactory cement distribution (OR, 3.004; 95% CI, 1.483–6.837), vertebral compression height > 4 mm (OR, 3.319; 95% CI, 1.376–5.766), and fracture site in lumbar spine (OR, 1.457; 95% CI, 1.137–2.769). The occurrence of acute pain after percutaneous transluminal vertebroplasty in patients with thoracolumbar spine fracture is associated with a variety of factors, and the prediction model constructed in this study has good prediction accuracy, which can help to identify high-risk patients at an early stage and intervene.

Background: Originally, patients with unstable thoracolumbar spine fracture were treated using pedicle screw fixation, a conventional incision. However, the small incision percutaneous pedicle screw fixation (PPSF), a new device, has been recently introduced which could save surgery time, reduce blood loss and improve clinical recovery.&#x0D; Objective: This study aimed to evaluate postoperative outcomes of the PPSF, compared with the open pedicle screw fixation (OPSF) in conventional incision among patients with thoracolumbar fracture.&#x0D; Methods: A retrospective study of 54 cases of patients with thoracolumbar spine fracture without neurological deficit was included in the study. The data were collected from medical records of patients admitted to Rayong Hospital from January 2017-December 2019. Results: Patients aged from 18-46 years (32.35+ 8.52) were mostly males (59.2%). Types of fracture included burst (72.22%). The most common level of thoracolumbar spine fracture was L1 (37.04%). Mostly, the cause of injury was fall from height (53.70%). The mean postoperative stays in the PPSF and OPSF groups were significant, 3.09±.59 and 6.16±1.003 days, respectively (p&lt;0.05). The mean intraoperative blood losses of the PPSF and OPSF groups significantly differed, 44.35±15.02 and 466.13±87.92 mL, respectively (p &lt; 0.01). However, the mean kyphotic angle reduction of the PPSF (24.43±2.74 degrees) and OPSF (24.87±2.55 degrees) groups did not significantly differ (p &gt; 0.1). The mean postoperative pain score (VAS) at the first day in the PPSF and OPSF groups were 6.43±.94 and 6.61±.98, respectively, which did not significantly differ (p &gt; 0.1).&#x0D; Conclusion: PPSF spinal fracture treatment could reduce the amount of bleeding during surgery and reduce the length of hospital stay. However, the results of both types of surgery did not differ regarding postoperative pain, decreased kyphotic angle and surgical time.

BackgroundSleep quality problems are common in patients with cancer, and the likelihood of sleep disorders is high in postoperative patients. Patients with oesophageal cancer are prone to postoperative problems with sleep quality owing to the complexity of the surgery. Therefore, we aimed to understand sleep quality of patients after oesophageal cancer surgery, analyse the factors that influence sleep quality, and provide theoretical references to improve the sleep quality of patients after oesophageal cancer surgery.MethodsA self-designed general information questionnaire, the Pittsburgh Sleep Quality Index (PSQI) and the Hospital Anxiety and Depression Scale were used to conduct a questionnaire survey. This questionnaire was used to survey 119 patients who underwent oesophageal cancer surgery at our hospital's thoracic department from October 2020 to June 2021. Statistical methods such as Spearman correlation analysis and multiple regression analysis were used to analyse the sleep quality of the patients and explore the factors that influenced sleep quality.Results(1) Among the 119 postoperative oesophageal cancer patients included in the study, 116 patients (97.48%) experienced sleep disturbance (PSQI≥7). The mean PSQI scores were 15.19±3.95; 60.5% (72/119) of patients experienced anxiety, and 48.74% (58/119) experienced depression. (2) Spearman correlation analysis revealed that patients' sleep quality scores negatively correlated with level of education and surgical approach (correlation coefficients of -0.23 and -0.27, respectively, P<0.05) and positively correlated with pain scores and nutritional risk (correlation coefficients of 0.26 and 0.17, respectively, P<0.05). The results revealed no correlation between anxiety or depression scores and PSQI scores. The average monthly household income was correlated with level of education, home residence, a burden of medical expenses, postoperative complications, and anxiety scores (correlation coefficients were 0.17, -0.28, -0.47, 0.26, and-0.24, respectively; P<0.05). The burden of medical expenses was also correlated with level of education and home residence (the correlation coefficients were -0.16 and 0.22, respectively; P<0.05). Postoperative complications were positively correlated with anxiety scores and depression scores (correlation coefficients were 0.34 and 0.27, respectively, P<0.05). (3) Multiple regression analysis revealed that surgical approach, pain scores, level of education, and nutritional risk scores affect the sleep quality of patients (95% CI=9.83–17.48, adjusted R2=0.23, P<0.05).ConclusionsThe postoperative sleep quality of Chinese oesophageal cancer patients was generally poor, which was related to the surgical approach, education level, pain score, and nutritional risk score. Anxiety, depression scores, and average monthly household income may also indirectly affect sleep quality. These findings suggest that clinical caregivers should consider the above factors in the prevention and treatment of relevant symptoms to improve the sleep quality of patients.

Chronic sleeplessness is a primary clinical symptom of vascular depression (VaDep). We investigated the efficacy and safety of escitalopram plus tandospirone citrate for patients with VaDep and chronic insomnia and the potential correlation of insomnia severity with neurotransmitter indexes, including serotonin (5-HT), serotonin 2C receptor (5-HT2CR), serotonin 7 receptor (5-HT7R) in platelets, and plasma 5-HT. This double-blind, randomized controlled study randomized patients with VaDep and chronic insomnia [Hamilton depression rating scale (HAMD) > 17 points] into a monotherapy group [escitalopram (10 mg once daily) plus placebo] or combined group [escitalopram (10 mg once daily) plus tandospirone citrate (10 mg three times daily)] by using a 1:1 assignment algorithm generated by SPSS 25.0 software. The primary endpoint was the change in sleep quality from baseline to week 12, evaluated by the Pittsburgh Sleep Quality Index (PSQI), polysomnography (PSG), Epworth Sleepiness Scale, and Asen Self-Rating Insomnia Scale (AIS). Secondary outcomes were the changes in depression and anxiety assessment and the levels of peripheral blood neurotransmitters from baseline to week 12, including HAMD, the Hamilton anxiety scale (HAMA), 5-HT, 5-HT2CR, 5-HT7R in platelets, and plasma 5-HT. The levels of 5-HT, 5-HT2CR, and 5-HT7R were detected with the enzyme-linked immunosorbent assay kits. The safety assessment included the Treatment-Emergent Symptom Scale and clinical and laboratory variables. The therapeutic improvement was analyzed by a generalized estimation equation. A total of 123 subjects (30.89% male) were included, with a mean age of 70.56 ± 6.37 (mean ± standard deviation, SD) years. In the monotherapy group, the baseline HAMD and PSQI scores (n = 61 for both) were 28.84 ± 2.49 and 14.16 ± 1.86, respectively. In the combined group, the baseline HAMD and PSQI scores (n = 62 for both) were 28.81 ± 2.51 and 14.21 ± 1.87, respectively. The HAMA and HAMD scores in both groups were significantly lower at weeks 4, 8, and 12 after treatment than before treatment (P < 0.001). Compared with the monotherapy counterpart, the combined group displayed significantly lower PSQI and AIS scores at weeks 4, 8, and 12 and improved PSG sleep macrostructure at week 12, including total sleep time (TST), sleep latency, sleep efficiency, sleep maintenance rate (SMT), wake time after sleep onset, and percentage of sleep in each phase. Platelet 5-HT, plasma 5-HT, and platelet 5-HT7R decreased in both groups at the end of weeks 4, 8, and 12 of treatment. Platelet 5-HT7R was moderately negatively correlated with the percentage of nonrapid eye movement 3 sleep time (N3). Plasma 5-HT was moderately positively correlated with PSQI and AIS and negatively with TST, SMT, nonrapid eye movement 2 sleep time (N2), and percentage of N2 sleep time. No statistical difference in the total incidence of adverse events was found between the two groups (P = 0.842). The statistically significant changes in PSG, PSQI, and AIS may indicate that the combination of escitalopram and tandospirone may improve, with a reasonable safety profile, the sleep quality of patients with VaDe. The clinical results observed were associated with changes in measures of plasma 5-HT and platelet 5HT7R; these findings suggest that a possible role of central serotonergic function in the mechanism of action of the drug combination in this trial could be a relevant subject of future studies. ChiCTR2300075407.

ObjectivesInsulin-like growth factor 1 (IGF-1) is a crucial neurotrophin that is produced in the brain and periphery and may play an important role in insomnia and mood disorders. We aimed to analyze its serum concentrations in patients with chronic insomnia disorder (CID).MethodsPatients with CID were enrolled in this study and divided into the CID group [Generalized Anxiety Disorder-7 (GAD-7) score < 10] and the CID with anxiety group (GAD-7 score ≥ 10). Age-and sex-matched healthy volunteers were recruited as controls. The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality and the GAD-7 and the Patient Health Questionnaire-9 to assess emotional status. All subjects were monitored via polysomnography, and the serum IGF-1 concentrations in their peripheral blood were detected via enzyme-linked immunosorbent assays.ResultsWe enrolled 65 patients with CID (of whom 35 had anxiety) and 36 controls. The PSQI score and IGF-1 concentration in the CID and CID with anxiety groups were higher than those in the control group. The apparent difference in IGF-1 concentration between the CID and CID with anxiety groups was not statistically significant. The IGF-1 concentration in patients with CID was linearly correlated with the GAD-7 score, PSQI score, and stage 3 non-rapid eye movement (stage N3) time.ConclusionThe serum IGF-1 concentration in patients with CID was lower than that of participants without CID, negatively correlated with anxiety score and sleep quality, and positively correlated with stage N3 time.

BackgroundCo-morbid depression and anxiety occur in the context of rheumatoid arthritis (RA). Their characteristics, including associations with RA features, have not been examined previously in an early RA inception cohort...

To compare the clinical effects of interactive dynamic scalp acupuncture (IDSA), simple combination therapy (SCT), and traditional scalp acupuncture (TSA) on cognitive function, depression and anxiety in patients with post-stroke cognitive impairment. A total of 660 patients with post-stroke cognitive impairment who were admitted to 3 hospitals in Shenzhen City between May 2017 and May 2020 were recruited and randomly assigned to the IDSA (218 cases), SCT (222 cases) and TSA groups (220 cases) according to a random number table. All the patients received conventional drug therapy for cerebral stroke and exercise rehabilitation training. Scalp acupuncture and computer-based cognitive training (CBCT) were performed simultaneously in the IDSA group, but separately in the morning and in the afternoon in the SCT group. The patients in the TSA group underwent scalp acupuncture only. The course of treatment was 8 weeks. Before treatment (M0), 1 (M1) and 2 months (M2) after treatment, as well as follow-up at 1 (M3) and 2 months (M4), the cognitive function of patients was assessed using the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment Scale (MoCA) Scales; depression, anxiety, sleep quality, and self-care ability of patients were assessed using Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Rating Scale (HAMA), Pittsburgh Sleep Quality Index (PSQI), and Modified Barthel Index (MBI), respectively. During this trial, all adverse events (AEs) were accurately recorded. There were no significant differences in the MMSE, MoCA, HAMD, HAMA, PSQI, and MBI scores among the 3 groups at M0 (all P>0.05). In the IDSA group, the MMSE, MoCA and MBI scores from M2 to M4 were significantly higher than those in the SCT and TSA groups, while the HAMD, HAMA and PSQI scores were significantly reduced (all P<0.01). The changes of all above scores (M2-M0, M4-M0) were significantly superior to those in the SCT and TSA groups (all P<0.01, except M4-M0 of HAMD). At M2, the severity of MMSE, HAMD, HAMA, PSQI and MBI in the IDSA group was significantly lower than that in the SCT and TSA groups (all P<0.01). There was no serious AE during this trial. IDSA can not only significantly improve cognitive function, but also reduce depression, anxiety, which finally improves the patient's self-care ability. The effect of IDSA was significantly better than SCT and TSA. (Trial registration No. ChiCTR1900027206).

Aims: Sleep is altered during pregnancy, particularly during the third trimester. Low Vitamin D levels have been linked to shorter sleep duration, depression and anxiety. In the NiPPeR double-blind randomised controlled trial of nutritional supplementation, women received either a formulation with additional ingredients including Vitamin D (‘intervention group’) or standard prenatal vitamins (‘control group’). The association between Vitamin D deficiency, sleep, depression and anxiety was examined from pre-conception to six months post-partum. We aimed primarily to determine if women deficient in Vitamin D (&lt;50nmol/L) were more likely to have disordered sleep compared with those Vitamin D sufficient. A secondary aim was to examine if women deficient in Vitamin D were more likely to be depressed or anxious compared with those with adequate Vitamin D levels.Methods: We examined sleep data from women with at least one measurement of Vitamin D in the pregnancy and post-delivery periods (n=515). Pittsburgh Sleep Quality Index (PSQI) scores were compared between those with sufficient or deficient Vitamin D levels: by convention a PSQI score of &gt;5 is considered to indicate disordered sleep. Depression was assessed using the Edinburgh Postnatal Depression Score (EPDS), with a score &gt;13 indicating depression. The State-Trait Anxiety short form scale was used to measure anxiety, with a cut off &gt;45 indicating state anxiety. One-way ANOVA in Stata version 18.0 was used throughout.Results: As reported previously, the intervention substantially reduced the proportion of women who were Vitamin D deficient during pregnancy but did not change EPDS scores; PSQI scores were also not changed by the intervention. In the combined control and intervention group total PSQI scores increased from pre-conception until six weeks post-delivery. Total hours of sleep declined from pregnancy weeks 19–20 to six weeks post-delivery. At recruitment preconception, PSQI scores were higher in those deficient in Vitamin D, compared with those with sufficient levels (p=0.015); at later time-points PSQI scores were higher in Vitamin D deficient women but not significantly so. Depression as assessed by EPDS &gt;13 was associated with Vitamin D deficiency only at preconception recruitment (p=0.019) and at 7 weeks’ gestation (p=0.004), but not later in pregnancy or post-delivery. There was no association found between anxiety and Vitamin D status.Conclusion: At pre-conception, sleep was worse in women with low Vitamin D levels. At preconception and early in pregnancy, low Vitamin D levels were associated with depression. Intervention with a Vitamin D containing supplement did not improve sleep in pregnant women.