Abstract
We present here a detailed molecular-level understanding of the interactions among surface-functionalized mesoporous SBA-15 silica and pharmaceutical guests that influence macroscopic adsorption and release behaviors. A model drug species, methylprednisolone sodium succinate, was adsorbed on the surfaces of functionalized mesoporous SBA-15 silica materials with different aminoalkyl species and without or with C60 fullerene moieties. Zeta potential measurements show that the electrostatic interactions among methylprednisolone species and modified silica surfaces are important for the adsorption and release of the methylprednisolone molecules. Complementary one and two-dimensional (2D) solid-state 13C{1H} NMR measurements provide evidence for specific intermolecular interactions between adsorbed methylprednisolone species and different types of functionalized silica surfaces. In particular, correlated 13C and 1H signal intensities from the methylprednisolone alkyl moieties and the aminoalkyl groups of the f...
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