Abstract
2012. Role of channel lysines and “push through a one-way valve” mechanism of viral DNA packaging motor. Biophys. J. 102:127–135. Peng Jing is now at the Department of Chemistry, College of Arts and Sciences, Indiana Purdue University Forte Wayne, Fort Wayne, Indiana. Role of Channel Lysines and the “Push Through a One-Way Valve” Mechanism of the Viral DNA Packaging MotorFang et al.Biophysical JournalJanuary 04, 2012In BriefLinear double-stranded DNA (dsDNA) viruses package their genomes into preformed protein shells via nanomotors using ATP as an energy source. The central hub of the bacteriophage φ29 DNA-packaging motor contains a 3.6-nm channel for dsDNA to enter during packaging and to exit during infection. The negatively charged interior channel wall is decorated with a total of 48 positively charged lysine residues displayed as four 12-lysine rings from the 12 gp10 subunits that enclose the channel. The standard notion derived from many models is that these uniquely arranged, positively charged rings play active roles in DNA translocation through the channel. Full-Text PDF Open Access
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