Abstract

Nature 346, 668-671 (1990) THIS letter in the 16 August 1990 issue of Nature reported that the protein product of the retinoblastoma susceptibility gene (RB-1) can repress c-fos expression and AP-1 transcriptional activity in both serum-induced and cycling 3T3 cells. We also identified a cis- actingelement in the human c-fos promoter that can confer repression by Rb to a heterologous promoter.

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