Abstract
[This corrects the article DOI: 10.1371/journal.pone.0160248.].
Highlights
We studied the effect of N-methyl-Nnitrosourea (MNU), a model SN1 methylating agent, on two human non small-cell lung cancer (NSCLC) cell lines; A549 (p53wt) and H157 (p53null)
The mechanism of MNU-induced cell death was investigated through a time course gene expression profiling study, 24, 48 and 72h following treatment
Gene Ontology-based analysis revealed that the most significantly altered processes, regarding A549 cells, were DNA damage response and repair, mitotic relative functions, cell cycle and proliferation while in H157 cells, they were mainly related to transcription regulation, cholesterol and fatty acid biosynthesis, apoptosis, inflammatory response, cell cycle and adhesion
Summary
The Abstract can be viewed here: a1111111111 a1111111111 a1111111111 a1111111111 a1111111111 Lung cancer remains the leading cause of cancer death worldwide, new therapeutic approaches are eagerly needed. Methylating agents of SN1 type constitute a widely used class of anticancer drugs, the effect of which on human non small-cell lung cancer (NSCLC) has not been adequately studied frequently combined with platinum-based chemotherapy.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
