Abstract
In 2004, the Journal of Hospital Infection published our letter ‘High-level disinfection of cystoscopic equipment with ortho-phthalaldehyde solution’. 1 Hamasuna R. Nose K. Sueyoshi T. et al. High-level disinfection of cystoscope equipment with ortho-phthalaldehyde solution. J Hosp Infect. 2004; 57: 346-348 Abstract Full Text Full Text PDF PubMed Scopus (3) Google Scholar We discussed the usefulness of ortho-phthalaldehyde (OPA) for the high-level disinfection of urological equipment including rigid cystoscopes. At least one report, however, has documented patients who experienced allergic reactions including anaphylaxis following cystoscopy in urological practice. 2 Sokol W.N. Nine episodes of anaphylaxis following cystoscopy caused by Cidex OPA (ortho-phthalaldehyde) high-level disinfectant in 4 patients after cystoscopy. J Allergy Clin Immunol. 2004; 114: 392-397 Abstract Full Text Full Text PDF PubMed Scopus (59) Google Scholar These cystoscopes were flexible and disinfected with OPA, and the patients had undergone repeated cystoscopies and had a history of bladder cancer. This report concludes that OPA was the cause of anaphylaxis. As a result of this and other personal reports, Advanced Sterilization Products (ASP), the manufacturer of OPA (Cidex® OPA Solution), revised this product's Instructions for Use (IFU) to contra-indicate its use for the reprocessing of any urological instrumentation used to treat patients with a history of bladder cancer. Therefore, it is necessary that we revise some of the conclusions in our published letter regarding the use of OPA. 1 Hamasuna R. Nose K. Sueyoshi T. et al. High-level disinfection of cystoscope equipment with ortho-phthalaldehyde solution. J Hosp Infect. 2004; 57: 346-348 Abstract Full Text Full Text PDF PubMed Scopus (3) Google Scholar
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