Abstract
Figure 1 ROI Placement and Flow-Time-Curves. Phase contract MRI images of the CSF for a patient with scleroderma-associated PAH (mPAP 49 mmHg) during rest (top row: A, B) and adenosine-induced stress (bottom row: D, E). The red ROI is drawn around the coronary sinus, the blue ROI is placed in adjacent myocardium to correct for through-plane motion. The flow-time curves (C, F) demonstrate that net CSF increased only slightly from rest (0.86 ml/min/g) to stress (1.32 ml/min/g), resulting in a CFR of 1.53. Correspondingly, there is only little change in the diameter of and flow signal within the coronary sinus.
Highlights
In pulmonary arterial hypertension (PAH) increased pressure and resistance in the pulmonary vascular bed cause right ventricular (RV) hypertrophy with increased myocardial oxygen demand
Studies in animals with RV hypertrophy demonstrated maintained resting but reduced stress perfusion and coronary perfusion reserve, which may contribute to RV failure
On multivariate linear regression analysis, RV mass/BSA was the main predictor of CFR for PAH patients
Summary
In pulmonary arterial hypertension (PAH) increased pressure and resistance in the pulmonary vascular bed cause right ventricular (RV) hypertrophy with increased myocardial oxygen demand. Studies in animals with RV hypertrophy demonstrated maintained resting but reduced stress perfusion and coronary perfusion reserve, which may contribute to RV failure. Purpose The purpose of our study was to investigate myocardial perfusion by comparing coronary sinus flow reserve. Johns Hopkins University School of Medicine, Baltimore, MD, USA PAH.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
