Abstract
Beeri et al. describe an interesting postmortem study of Alzheimer disease (AD) patients and controls.1 We have also investigated coronary atherosclerosis, cardiovascular disease, and cardiac valve pathology in AD subjects and controls.2 The number of autopsies examined in our study was similar to that reported by Beeri et al. We analyzed general systemic autopsy data from 84 neuropathologically confirmed AD patients and from 60 non-AD control patients using a grade of membership model. All cases of AD were Braak stage IV, V, or VI. Consistent with reports from our center3 and others, the late onset AD groups had elevated APOE e4 frequency. However, the late onset AD groups also had frequent mitral and aortic valve dilation, evidence of ventricular pathology, or both. In contrast to the report by Beeri et al., we observed only modest systemic and coronary atherosclerosis in the …
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