Abstract
The aim of this observational study was to examine the characteristics of anterior and posterior corneal topography in keratoconic eyes more than 30 years after penetrating keratoplasty (PK). Patients who maintained clear grafts for more than 30 years after PK were included and divided into the keratoconus (KC) group or other diseases (Others) group, based on the primary indication. Twenty-six eyes of 26 patients were included. The KC group and the Others group included 14 eyes and 12 eyes, respectively. The KC group participants were younger at the time of surgery (P = 0.03). No differences were found in best-spectacle-corrected visual acuity, keratometric power, and central-corneal-thickness. Based on corneal topography using Fourier harmonic analyses, regular astigmatism in the anterior cornea was significantly larger (P = 0.047) and the spherical component in the posterior cornea was significantly lower (P = 0.01) in the KC group. The area under the receiver operating characteristic curve of the spherical component, regular astigmatism, asymmetry component, and higher-order irregularity were 66.07%, 63.10%, 57.14%, and 59.23%, respectively, in the anterior cornea and 80.65%, 52.98%, 63.10%, and 63.99%, respectively, in the posterior cornea. Our results suggested that Fourier harmonic analysis of corneal topography could be useful for patients with KC long after PK.
Highlights
Since the first successful operation performed by Eduard Konrad Z irm[1], many investigators have demonstrated that penetrating keratoplasty (PK) has long-term efficacy and s afety[2,3,4]
The current study aimed to examine the characteristics of corneal topography with Fourier harmonic analysis in KC patients who had received PK more than 30 years earlier
No significant difference was found between the KC group and the other diseases (Others) group in terms of sex, postoperative time, best spectacle-corrected visual acuity (BSCVA), intraocular pressure (IOP), central corneal thickness (CCT), thinnest corneal thickness (TCT), and endothelial cell density (ECD) (Table 1)
Summary
The aim of this observational study was to examine the characteristics of anterior and posterior corneal topography in keratoconic eyes more than 30 years after penetrating keratoplasty (PK). Corneal topography with Fourier harmonic analysis, which can decompose refractive data into four components (i.e., spherical, regular astigmatism, asymmetry, and higher order irregularity), has been used to investigate corneal irregular astigmatism in various keratoconjunctival diseases[11,12,13] and the outcome of surgeries[14,15,16,17,18,19,20], and to detect subclinical KC21. N Sex (men:women) Age at the operation (years) Postoperative term (years) Age at the analysis (years) Best-spectacle-corrected visual acuity (logMAR) Intraocular pressure (mmHg) Central corneal thickness (μm) Thinnest corneal thickness (μm) Corneal endothelial cell density (cells/mm2) Kmax (D) AvgK (D) Incidence of corneal neovascularization (%)
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