Abstract
The combination of magnetic nanoparticles and hydrogels affords magnetogels, improving the manipulation of physicochemical properties and widening the range of applications, such as magnetic resonance imaging, biosensing, hyperthermia, drug delivery and as a template material. The introduction of plasmonic properties will synergistically enhance anticancer therapeutic strategies on the desired target through photothermia, drug release and photodynamic therapy. In this work, superparamagnetic manganese ferrite (MnFe2O4) nanoparticles coated with a gold shell were successfully incorporated into a self-assembled peptide-based hydrogel linked to a naproxen group, a lysine residue to stabilize the gold nanoparticle surface, and a dehydroamino acid that provides protease resistance. The new magnetogel was evaluated as nanocarrier for the model drug curcumin and the photothermia potential of the nanosystem was assessed. Microstructural properties of the hydrogels and magnetogels were studied by CD. Fluorescence-based techniques (fluorescence emission, quenching and FRET) were used to assess hydrogel physicochemical properties, incorporation of drugs and drug transport towards model membranes. The developed magnetic/plasmonic nanosystem exhibited promising results for photothermia application in multimodal cancer therapy, though future combination with other hydrogels will be required to improve its applicability.
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