Core-shell structured magnetite carboxymethyl cellulose for cervical cancer treatment by maintaining methotrexate serum concentration

Abstract

In this work, we attempted to improve the properties of magnetite carboxymethyl cellulose nanoparticles (Mag CMC NPs) through Ugi multicomponent reaction (MCR) to obtain magnetite carboxymethyl cellulose@functionalized carboxamide nanoparticles (Mag CMC@FCA NPs) as a new nano bio-carrier. Typically, at first Mag CMC NPs prepared by the co-precipitation method. Then by performing the Ugi MCR on Mag CMC NPs, the Mag CMC@FCA NPs achieved better properties in swelling ratio, loading efficiency and loading capacity. The prepared Mag CMC@FCA NPs characterized in detail. Evaluation of the prepared system functionality showed the swelling rate increased from 294 % to 1472 %. Furthermore, for methotrexate (MTX), loading efficiency increased from 24.62 % for Mag CMC NPs to 57.25 % for Mag CMC@FCA NPs, and the drug loading capacity increased from 1.23 % to 2.86 %. The loading of Ampicillin (AMP) and MTX has been observed to have a beneficial effect. When AMP is placed in the metabolic pathway of MTX, it prevents biodegradation of MTX up to 35 %, which results in a longer duration of high MTX concentration in the blood. Consequently, the toxicity of the prepared medication on healthy cells of the body is reduced, and the death rate is decreased to some extent.