Abstract
Objective: to investigate whether there is any relationship between cord blood theophylline levels and pulmonary morbidities in the early neonatal period in premature infants.Study Design: This prospective cohort study was conducted in Hacettepe University Hospital Neonatology Unit, between November 2010 and January 2012. Cord blood samples were collected at birth from premature infants, and theophylline levels were measured. Theophylline levels of cord blood were compared between infants with and without pulmonary morbidity.Results: A total of 90 infants (42 females, 48 males) were enrolled in the study. The mean gestational age was 31.1±3.1 weeks, and the mean birth weight was 1527±540 g. Early respiratory morbidities developed in 57 infants (63.3%), while no respiratory morbidities were observed in 33 infants (36.7%). There was no significant difference between the groups in blood gas parameters, oxygen saturation values and cord blood theophylline levels.Conclusions: Although the theophylline levels that were measured in the cord blood were much lower than therapeutic serum levels, we concluded that the cord theophylline level is not valuable as a prognostic factor for pulmonary morbidities in premature newborns.
Highlights
Caffeine and theophylline are widely used drugs in the treatment of apnea of prematurity
Caffeine is mainly metabolized by the cytochrome P450 1A2 (CYP1A2), and another enzyme that regulates the metabolism to a lesser extent is N-acetyltransferase [2,6]
We aimed to investigate whether there is any relationship between cord blood theophylline levels and pulmonary morbidities in the early neonatal period in premature infants
Summary
Caffeine and theophylline are widely used drugs in the treatment of apnea of prematurity As respiratory stimulants, they are used to weaning from mechanical ventilation [1, 2]. These drugs and their precursors are taken in via certain daily foods Methylxanthines such as caffeine and its metabolites (paraxanthine, theophylline, and theobromine) are available in tea, coffee, cocoa, cola, and chocolate [3,4]. There are no significant differences in plasma levels of theophylline between the maternal and fetal circulations [2] It is not known what effects caffeine and its metabolites, which are taken through the maternal diet during the fetal period, have on the respiratory system in the early neonatal period
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