Copper iodide and ZnO nanoparticles catalyzed multicomponent synthesis of 1,3-cyclopentadiene: study of antioxidant activity

Abstract

Zinc oxide (ZnO) nanoparticles, as a simple and recyclable catalyst, were easily synthesized and used for the synthesis of 1,3-cyclopentadiene derivatives by a four-component reaction of terminal alkynes, sulfonyl azides, activated acetylenic compounds, and isocyanides in the presence of copper iodide in acetonitrile at room temperature. In these reactions, 1,3-cyclopentadiene derivatives were obtained in good yield and in a short reaction time. In this research, antioxidant activity was investigated for the some newly synthesized compounds such as 5a–5d using the DPPH radical trapping and reducing potential tests of ferric ion and comparing results with synthetic antioxidants (TBHQ and BHT). In this study, compounds 5a–5d show good DPPH radical trapping and excellent reducing power of ferric ion.