Abstract
Copper deficiency (hypocupremia) is an acknowledged but often overlooked cause of anemia and leukopenia (1-4). It is recognized as a frequent cause of hypochromic microcytic anemia, leukopenia, and neuropathy. Copper deficiency anemia has been reported after gastric resection (e.g., Roux-en-Y) (1, 5, 6), excessive zinc consumption (1, 6-9), and in patients with short bowel syndrome receiving total parenteral or enteral nutrition lacking adequate copper supplementation (1, 2). We report a case of vitamin B12, and iron refractory severe anemia and leucopenia with history of Roux-en-Y surgery. Myelodysplastic syndrome was suspected. Bone marrow biopsy was consistent with copper deficiency and serum copper levels were undetectable. The patient experienced complete hematological recovery after copper replacement therapy.
Highlights
Copper deficiency is an acknowledged but often overlooked cause of anemia and leukopenia [1,2,3,4]
The myeloid lineage showed scattered a frequent cause of hypochromic microcytic anemia, precursors, including myelocytes with cytoplasmic leukopenia, and neuropathy
We report a case of vitamin B12, with primary myelodysplasia, other sideroblastic and iron refractory severe anemia and leucopenia with anemias such as chronic alcohol toxicity, chronic history of Roux-en-Y surgery
Summary
Copper deficiency (hypocupremia) is an acknowledged but often overlooked cause of anemia and leukopenia [1,2,3,4]. It is recognized as cells), rare nuclear contour irregularities, and cytoplasmic vacuolization of scattered erythroid precursors. The myeloid lineage showed scattered a frequent cause of hypochromic microcytic anemia, precursors, including myelocytes with cytoplasmic leukopenia, and neuropathy.
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