Abstract
A single pot, wet chemical route has been applied for the synthesis of polymer supported copper azide, CuN3, nanoparticles (CANP). The hybrid system was used as ‘catalyst-cum-reagent’ for the azide-alkyne cyclo-addition reaction to construct triazole molecules using substituted benzyl bromide and terminal alkyne. The electron donating group containing terminal alkyne produced 5-alkynyl 1,4-disubstituded triazole product whereas for alkyne molecule with terminal electron withdrawing group facilitate the formation of 1,4-disubstituted triazole molecule.
Highlights
A single pot, wet chemical route has been applied for the synthesis of polymer supported copper azide, C uN3, nanoparticles (CANP)
We have engaged in the search of effective catalysts for different organic transformations reactions[20,21,22,23,24,25,26]
We have describe a step-wise route for the synthesis of copper azide nanoparticles (CANP) and applied this material as ‘catalyst cum reagent’ where Cu(I) was performed as a catalytic role and azide counterpart acted as nucleophilic role for azide-alkyne cyclo-addition reaction to construct triazole molecules
Summary
1 (1.0 equivalent), terminal alkyne 2 (2.0 equivalent or 1.0 equivalent for EWG attached alkyne), were mixed in 4 mL of solvent (methanol) To this reaction mixture, CANP (200 mg, 1.0 equivalent) and Et3N (240 μL, 2.0 equivalent or 140 μL, 1.0 equivalent for EWG attached alkyne) was added and allowed to stir for 3 h. In a 25 mL round bottom flask, sugar azide 5 (1 equivalent), terminal alkyne 2 (1 equivalent), were charged in 4 mL methanol. To this reaction mixture the dried recovered catalyst (10 mg) and E t3N (1 equivalent) was added and allowed to stir for 3 h. Data collection: APEX2 2014-11; cell refinement: SAINT v8.38A; data reduction: SAINT v8.38A; program used to solve structure: SHELXT 2014/5; program used to refine structure: SHELXL 2018/3; molecular graphics: Olex[2]; software used to prepare material for publication: Olex[2], PLATON
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