Abstract
Synthesis of poly(PDL-GA) copolymers is successfully achieved via enzymatic catalysis starting from ω-pentadecalactone and ethyl glycolate. In the copolymers PDL and GA units show a significant tendency to an alternating arrangement. All copolyesters display a high degree of crystallinity (χc≈70%) regardless of their composition (GA content: 0–27mol%). Analysis of melting point depression by the Wendling–Suter model suggests inclusion of GA units in PPDL-type crystals. Accordingly WAXS results show that, with increasing GA unit content, the PPDL unit cell undergoes a gradual increase of c-axis (chain axis) periodicity, compatible with the insertion of GA units within the crystallizing PDL sequences. Poly(PDL-GA) copolymers combine typically hydrophobic (PDL) and hydrophilic (GA) monomers and are promising new tuneable drug-delivery systems for medical applications. In this perspective, poly(PDL-GA) nanoparticles are fabricated and characterized.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
