Abstract
The perceptible appearance of biomolecules as prospective building blocks in the architecture of coordination polymers (CPs) and metal-organic frameworks (MOFs) are redolent of their inclusion in the synthon/tecton library of reticular chemistry. In this frame, for the first time a synthetic strategy has been established for amine derivatization in amino acids into 1,2,4-triazoles. A set of novel 1,2,4-triazole derivatized amino acids were introduced as superlative precursors in the design of 1D coordination polymers, 2D chiral helicates and 3D metal-organic frameworks. Applications associated with these compounds are diverse and include gas adsorption-porosity partitioning, soft sacrificial matrix for morphology and phase selective cadmium oxide synthesis, FeII spin crossover materials, zinc-b-lactamases inhibitors, logistics for generation of chiral/non-centrosymmetric networks; and thus led to a foundation of a new family of functional CPs and MOFs that are reviewed in this invited contribution.
Highlights
With its variety of topologies and wide applications, reticular chemistry attained a distinct position in classical coordination chemistry [1,2,3,4,5,6,7,8,9,10,11,12,13]
Coordination polymers (CPs) and networks (CNs), metal-organic frameworks (MOFs), organic-inorganic hybrid solids are some of the terminologies extensively encountered in this discipline where dimensionality, nature of interactions, permanent porosity draw a line of demarcation among them
Crafts of organic synthesis to design desired molecular fragments with the advantage of post-synthetic modification leads to diverse CPs/MOFs when integrated with directional properties of different metal ions across the periodic table [6,7,8,9,10,11,12,13,14]
Summary
With its variety of topologies and wide applications, reticular chemistry attained a distinct position in classical coordination chemistry [1,2,3,4,5,6,7,8,9,10,11,12,13]. Keeping potential carboxylic group untouched, derivatization of amine terminal in amino-acids to a moiety that could act as bridging group would be highly desirable in the construction of high dimensional porous network and controlled generation of coordination polymers In this direction, building a N-heterocycle (e.g., 1,2,4-triazole) on the amine terminal in an aminoacid would be a benefit in reticular chemistry and from a synthetic point of view in medicinal chemistry. Vs three zinc-β-lactamases which is considered as a step towards the design of inhibitors for metallo-β-lactamases [54] (b) applicability of CP like 3 as suitable sacrificial matrix for generating morphology and phase selective cadmium oxides (c) illustrating with 2 and 3 advantage of achiral synthon in controlling dimensionality of network and introducing chirality in the network, respectively [55] (d) a 3D porous nanoball CuII MOF and associated sorption properties and porosity partitioning [53] and (e) 1D FeII spin crossover CP with L1 that act as ‘optical alert’ at room temperature, which is a highly desirable material in molecular electronics [17].
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