Abstract
Sb(III) complexes of 3-aminoquinoxaline-2-carbonitrile 1,4-dioxides were prepared in order to improve the anti-Trypanosoma cruzi activity of these ligands. The in vitro evaluations demonstrated that in general upon metal complexation the activity of the 3-aminoquinoxaline ligands increased. Except for one compound, with solubility problems, coordination to antimony resulted in 2- to 12-fold increase of the trypanosomicidal activity. In addition, these complexes were equally or more active against T. cruzi than other metallic complexes with the same ligands previously evaluated in the same conditions. Computational study was performed in order to explain the effect of these metals in the anti-T. cruzi activity of 3-aminoquinoxaline-2-carbonitrile 1,4-dioxide ligands.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
