Abstract
Postural orthostatic tachycardia syndrome (POTS) is an abnormal heart rate response to a positional change. Several potential mechanisms for pathophysiology of POTS are defined. This syndrome can coexist with different clinical situations. In our report, the first case was a 13-year-old female who has been followed up for diagnosis of homocystinuria. She was admitted to our outpatient clinic with complaints of dizziness after suddenly moving from supine to upright position and chest pain after exercise. Tilt table test was performed to evaluate dizziness. According to the tilt table test the patient was diagnosed with POTS. The second case was a 17-year-old female who had been evaluated in different centers with the complaints of fainting, bruising, redness, and swelling on the hands and feet after moving from supine position to upright position during the last 4 years. Postural orthostatic tachycardia syndrome was diagnosed by tilt table test and ivabradine was started. Herein, we aimed to point out the cooccurrence of different clinical entities and POTS.
Highlights
Postural orthostatic tachycardia syndrome (POTS) is a kind of autonomic dysfunctions with abnormal heart rate response to positional change [1]
Tilt table test is performed to make the diagnosis and exclude other causes that may lead to autonomic dysfunctions [1]
POTS may overlap with many disorders like diseases of the basic cellular matrix and connective tissue [2]
Summary
Postural orthostatic tachycardia syndrome (POTS) is a kind of autonomic dysfunctions with abnormal heart rate response to positional change [1]. POTS may overlap with many disorders like diseases of the basic cellular matrix and connective tissue [2]. Raynaud phenomenon may accompany POTS and when the two of them are seen together, other causes should be excluded such as connective tissue diseases. We present two patients with clinical diagnosis of POTS and two different cooccurrences of Raynaud phenomenon, homocystinuria, and POTS. This is the first case in the literature reporting the cooccurrence of POTS and homocystinuria. In this case report, we aimed to point out the possibility of cooccurrence of different clinical entities and POTS
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