Abstract
To the Editor.— The report by Litovitz and Troutman entitled Amoxapine Overdose, Seizures, and Fatalities1prompts me to describe three cases from my practice of seizures associated with the therapeutic use of amoxapine. Report of Cases.—Case 1.— A 58-year-old man with major recurrent depression of two years' duration previously refractory to antidepressant drugs and electroconvulsive therapy had responded to a combination of lithium and amoxapine. He had no history of seizures or drug or alcohol abuse. At the time of the seizure, his medications included lithium carbonate, 1,200 mg daily in divided dose, amoxapine, 600 mg daily in divided dose, and liothyronine sodium, 25 μg daily. He had a single witnessed partial motor seizure involving his right upper extremity. The amoxapine dose was reduced to 400 mg/day, the liothyronine therapy was discontinued, and during 18 months of follow-up there have been no further seizures. Anticonvulsant drugs were
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: JAMA: The Journal of the American Medical Association
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
