Abstract
MPTP (1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine) causes selective and irreversible degeneration of the substantia nigra of human and non-human primates. In the central nervous system, the oxidative metabolism of MPTP to 1-methyl-4-phenyl-pyridinium (MPP +) by monoamine oxidase type B (MAO-B) seems to be a critical feature in the neurotoxic process. We now report that [ 3H]MPTP is rapidly converted in vitro into [ 3H]MPP − by human platelet MAO-B. The formation of [ 3H]MPP + in human platelets is prevented by specific MAO-B but not by MAO-A or by 5-hydroxytryptamine uptake inhibitors.
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