Abstract

Abstract Stereotactic neurosurgery involves a targeted intervention based on congruence of image-guidance to a reference fiducial system. This discipline now has widespread applications in radiosurgery, tumor therapy, drug delivery, functional lesioning, and neuromodulation. In this article, we focus on convection-enhanced delivery to deliver therapeutic agents to the brain and comment on areas of research and clinical development. This study employed a robust literature review of all relevant articles highlighting the current efforts and challenges of making this delivery technique more widely understood. We further describe the key biophysical properties of molecular transport in the extracellular space that may impact the efficacy and control of drug delivery using stereotactic methods. Understanding these principles is critical for further refinement of predictive models that can inform advances in stereotactic techniques for the convection-enhanced delivery of therapeutic agents to the brain.

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