Abstract
Layered double hydroxide (LDH) nanoparticles (NPs) have found various potential applications in control delivery of therapeutics, including many negatively charged drugs, oligonucleotides, genes, and peptides/proteins. The current study specifically investigated the surface coating with mesoporous silica (mSiO2) to make an LDH@mSiO2 core/shell structure and precisely control the release of the payload. Mg2Al-LDH NPs were coated with mSiO2 by varying the reagent concentration and the chain length of cationic surfactants in order to tailor the thickness and the pore size of the mSiO2 shell. TEM images and FTIR spectra evidenced the successful mSiO2 coating onto the surface of LDH NPs. Within the tested conditions, the thickness of the mSiO2 shell can be tailored from 5 to 20 nm and the pore size from 1.9 to 3.3 nm. We further demonstrated that the exchanging property of Mg2Al-Cl-LDH NPs, combined with the diffusion control of the mSiO2 shell, resulted in an effective controlled release of the payload. Thus we have established a foundation for the development of a multifunctional smart delivery platform.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
