Controlling a possible outbreak of Candida auris infection: lessons learnt from multiple interventions

Abstract

Multidrug-resistant Candida auris infection has been reported from five continents in recent years. The prevalence of C.auris invasive infection has been estimated at 5.3% for intensive-care-acquired candidaemia in India. The transmission of the organism between the patients and from environment to patients is rapid. To understand the intra-hospital dynamics of C.auris transmission and to determine the possible interventions to prevent its spread. Surveillance of intensive care units was carried out to assess patient colonization, environmental contamination and hand carriage of the yeast among healthcare workers. Interventions including chlorhexidine washing of patients and decontamination of environmental surfaces with stabilized hydrogen peroxide disinfectant (Ecoshield) were undertaken. We further evaluated the effectiveness of frequently used disinfectants in the hospital against C.auris on various inanimate surfaces, and its persistence on hospital fabrics. Three cases of C.auris bloodstream infection were detected over a period of three months. Many patients admitted at the same time, in the same area, were colonized by C.auris. Surveillance detected C.auris contamination of environmental surfaces and hands of healthcare workers. Interventions such as chlorhexidine washing and appropriate use of disinfectants could eradicate C.auris from patients and hospital environment. The frequently used disinfectants in our hospital and current hand hygiene practices were efficient against C.auris if proper contact time and procedures were followed. Evaluation of possible persistence of C.auris on dry fabrics showed that they can persist for up to seven days.