Abstract
Electrospun polycaprolactone nanofibers with embedded magnetic nanoparticles were developed for use in the topical delivery of antipsoriatic drugs. To test a hydrophobic drug, a tazarotene has been used, which is an efficient retinoid derivative. Such a smart hyperthermia nanofiber system with self-generated heat from the incorporated magnetic nanoparticles induced drug release in response to on–off switching of alternating magnetic fields for the delivery of tazarotene through the skin, as quantified using Franz cells. This highly efficient external field-controllable system with minimal skin irritation could create a new avenue for the topical therapy of psoriasis.
Highlights
Psoriasis is a hereditary, chronic, and recurrent immune-based disease, which is characterized by the incomplete maturation and differentiation of skin cells
Exogenous and endogenous factors play a significant role in the development of clinical manifestations of psoriasis, as they can induce a clinical manifestation of psoriasis in patients with a latent form of the disease
We address a more challenging task, namely the delivery of a drug with poor water solubility, tazarotene, using a nanofiber patch made of hydrophobic polycaprolactone polymer (Figure 2), an FDA-approved, biocompatible, and non-immunogenic semi-crystalline polymer with good biodegradability
Summary
Chronic, and recurrent immune-based disease, which is characterized by the incomplete maturation and differentiation of skin cells. It affects about 2–4% of the European population. After the removal of the scales, corticosteroids in the form of solutions are most often used in topical therapy as creams and ointments They have a non-specific anti-inflammatory, immunomodulatory, antiproliferative, and vasoconstrictive effects. Local retinoids react with the nuclear receptors of cells and affect the transcription of genes They have antiphlogistic, immunomodulatory, antiproliferative, and differentiating effects on keratinocytes, lymphocytes, and sebocytes [1]. The drug upregulates three genes, TIG-1 (tazarotene-induced gene-1), TIG-2, and TIG-3, which can mediate antiproliferative activity
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