Abstract
Solid dispersion films were prepared with a highly water-soluble medicine, lidocaine hydrochloride (LDC), water-insoluble ethylcellulose (EC) and water-soluble hydroxypropylcellulose (HPC). The release profiles of LDC from the solid dispersion films of different composition, and the suppression mechanism of the release in the LDC-EC-HPC system were studied. The release rate of LDC from the solid dispersion film as drug-reservoir was well controlled at EC/HPC composition ratio of 5/5. The mechanism of controlled release was speculated that there was a little release of HPC together with LDC, and the retained HPC was swelled in the film by the permeating fluid. Then, the release of LDC occurred via diffusion into the swelled HPC phase, causing a marked decrease in the release rate. The film for clinical use, which had the 30% LDC solid dispersion film, adhered almost completely to the buccal mucosa. These observations will provide useful information on clinical application of the LDC-EC-HPC solid dispersion film.
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