Abstract
The studies on the permeability of ethinylestradiol (EE) through ethylene-vinyl acetate (EVA) copolymer membrane using a two-chambered diffusion cell were carried out to develop the membrane controlled transdermal delivery system. To evaluate the effect of drug concentration in reservoir, polyethylene glycol (PEG) 400 was added to saline solution as a solubilizer and a sink condition was maintained in the receptor solution. An increased vinyl acetate comonomer content in the EVA membrane increased the drug release rate and permeability coefficient. A linear relationship existed between the permeation rate and the reciprocal of the membrane thickness. Ethinylestradiol-containing matrix was fabricated with EVA copolymer to control the release of the drug. The release of EE from EVA matrix follows a diffusion controlled model, where the quantity released per unit area is proportional to the square root of time. The release rate of drug from EVA matrix increased with PEG 400 volume fraction, temperature and loading dose.
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