Abstract
Mechanotransduction, the conversion of the external, environmental forces acting on a cell into internal biochemical signaling pathway, is now becoming a recognized route for delivering tissue-forming stimuli to therapeutic cells. In the body, complex loading forces transduced through tissue serve to inform cells of their physical environment and can therefore have profound effects on tissue homeostasis, regulating many aspects of cell behavior including proliferation, differentiation and ECM composition [1–4]. With this growing awareness of the role of cell biomechanics, several researchers have now started to focus their attention on exploiting these biomechanical pathways to resolve long-standing challenges in regenerative medicine – the optimal construction, repair and integration of tissues in the body.
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