Abstract
Silk fibroin (SF) films were prepared using a casting method and the structural change owing to treatment with methanol-water mixtures of different concentrations was investigated by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The results were used to reveal the influence of structure on the release dynamics of Rhodamine B, a model compound loaded in the SF matrix. In methanol concentration ranging from 50% to 90%, the content of silk II crystalline structure, constituted by β-sheet, first increased and then decreased with increasing methanol concentration in the mixtures, reaching a maxi- mum around 80%. It was found that Rhodamine B released from the SF film via Fickian mechanism, of which the diffusional exponent increased with increasing β-sheet content in the matrix, suggesting that the silk II crystal could be used as natural regulator for drug release from SF material.
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