Abstract

Herein a new drug loading and release device based on nanopore thin film and layer-by-layer (LbL) nanoassembly is reported. The nanopore thin film is a layer of anodic aluminum oxide (AAO), which consists of periodically distributed honeycomb-shape nanopores. Using LbL nanoassembly process, the drug (gentamicin sulfate (GS) as the model) can be loaded into the nanopores and the stacked layers on the nanopore thin film surface. This procedure can be monitored optically. As a technical demonstration, the drug release from the device is achieved by immersing it into flowing DI water, which again can be monitored optically. The simple preparation process and bio-compatibility of the device render it as a potential implantable controlled drug release device.

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