Abstract
BackgroundOne of the underlying assumptions of synthetic biology is that biological processes can be engineered in a controllable way.ResultsHere we discuss this assumption as it relates to synthetic gene regulatory networks (GRNs). We first cover the theoretical basis of GRN control, then address three major areas in which control has been leveraged: engineering and analysis of network stability, temporal dynamics, and spatial aspects.ConclusionThese areas lay a strong foundation for further expansion of control in synthetic GRNs and pave the way for future work synthesizing these disparate concepts.
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