Abstract
Erythroid cell differentiation has proved to be a useful system for exploring several aspects of gene expression during mammalian cell differentiation (1,2). In particular, fetal mouse erythropoiesis has been employed as a system to study: (a) the basis of changes in types of globins formed during fetal development; (b) mitotic activity of differentiating erythroblasts in relation to the synthesis of globins; (c) the number of structural genes coding for globins; (d) the relation of mRNA synthesis to globin formation during erythroid cell differentiation and (e) the mechanism of the erythropoietin effect in stimulating hemoglobin synthesis.
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