Control of Antibiotic Delivery from TCP along with HA on Bone Cement in the Interface Bioactive Bone Cement for Prevention of Infection in Joint Replacement

Abstract

Since 1985, HA granules were interposed on the interface between bone and bone cement at the cementation (Interface Bioactive Bone Cement : IBBC) in THA to prevent generation of connective tissue and osteolysis. To prevent infection, β-TCP impregnated with antibiotics along with HA granules was used. As TCP is resorbable, antibiotic release can be controlled. β-TCP granules were impregnated with antibiotics of folmoxef sodium (F), Vancomycine hydrochloride (V) cefortiam dihydrochloride (C) and cefozopran hydrochloride (CE). Three models of antibiotic release were assumed. Model [1] was antibiotic release from surroundings of β-TCP granules. Model [2] was the condition loaded under normal and reduced pressure. In Model [3], β-TCP was dissolved gradually in EDTA, as the model in the living body. In model [1], the amount of release of F, V and C was 3280, 300 and 3 µg, respectively and completed in 30 hours. In model [2], the amount of release of F, V, C and CE was 16, 8, 0 and 8000 µg in reduced pressure, respectively. The release of F, V and C completed within 24 hours and that of CE was in 6 days. In model [3], released amount of C and CE was 116 and 7100 µg, respectively and completed in 19 days.