Abstract
The techniques of electron microscopy was extensively used in our study on flavivirus replication. The initial event of attachment and entry of the virus was visualised (Fig 1). It revealed that virus (Vi) particle attachment (double arrow) was most likely receptor-mediated. Entry was through clathrin-coated endocytotlc vesicles (Eve). Uncoating of the virus envelope (short arrows) seemed to occur within the endocytotic vesicles.After entry and during replication, there are several virus-induced changes (Fig 2). Three most prominent features are the formation of vesicles (Ve), the microtubule paracrystals (Pc) and the proliferation of the endoplasmic reticulum (ER). These components are always in close vicinity to each other and could be the replication complex for the virus.
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