Abstract
Contribution of GFP Expressing Dermal Papillae Cells to the Formation of Chimeric Embryos and their Survival in Uterine Environment
Highlights
The capability of epigenetic reprogramming somatic cells to convert into embryonic stem- like cells attracts much attention because of the potential for customized transplantation therapy, as cellular derivatives of reprogrammed cells will not be rejected [1,2,3]
Innovative cell-based therapies have focused on the dermal papillae cells (DPCs) as a way to grow new hair in previously bald areas
Because of our interest in testing DP cells’ pluripotency under blastocyst control, we examined the development of microinjected embryos in vitro in the absence and presence of Mouse Embryonic Fibroblasts (MEFs)
Summary
The capability of epigenetic reprogramming somatic cells to convert into embryonic stem- like cells attracts much attention because of the potential for customized transplantation therapy, as cellular derivatives of reprogrammed cells will not be rejected [1,2,3]. Innovative cell-based therapies have focused on the dermal papillae cells (DPCs) as a way to grow new hair in previously bald areas. Current research in this area tended towards the use of developmental biology-based tissue engineering approaches to try to create a skin equivalent that will produce hair follicles when grafted in vivo [7,8]. Dermal cells in the lower end bulb region of hair follicles are highly active and able to differentiate down an endothelial lineage and they exhibit similar functional characteristics to endothelial cells in in vitro functional assays. The identification of dermal papillae cells’ properties is previously clearly documented in vivo and in vitro, confirmed in situ and detected by transmission electronic microscopy [15,16]
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