Abstract
BackgroundThe Prognostic value of microvessel density in cancer remains unclear. Recent studies have suggested that the uneven distribution of microvessels in tumours caused the variation in sample selection which led to different prognostic outcome. The enhancement pattern of Contrast-enhanced computed tomography (CECT) is determined in part by the microvessel distribution in solid tumors. Therefore, survival analysis of tumors grouping by the enhancement pattern and the pattern of microvessel distribution is important.MethodsSurvival analysis grouped by the tumor enhancement pattern and the microvessel distribution was carried out in 255 patients with invasive ductal carcinoma.ResultsThere were significant differences in overall survival (OS) and disease-free survival (DFS) among the homogeneous, heterogeneous and peripheral enhancement groups. There were significant differences between OS and DFS groups with uniform and uneven distributions of microvessels.ConclusionsThe distribution of microvessels in a tumor is a potential prognostic indicator in patients with breast cancer, and can be assessed by CECT prior the operation.
Highlights
The Prognostic value of microvessel density in cancer remains unclear
Microvessel density (MVD) assessment was once considered a useful indicator in the selection of those node-negative patients with breast carcinoma who are at high risk to have occult metastasis at presentation [2], and was an commonly used important technique to quantify angiogenesis in other solid tumours [3]
Survival analysis grouping by clinicopathological subtype One hundred and nineteen patients were classified as luminal A, 52 patients as luminal B with positive Ki67, 22 patients as luminal B with HER2 over-expression, 16 patients as HER2 over-expression, and 46 as triple- negative breast cancer
Summary
The Prognostic value of microvessel density in cancer remains unclear. Recent studies have suggested that the uneven distribution of microvessels in tumours caused the variation in sample selection which led to different prognostic outcome. Microvessel density (MVD) assessment was once considered a useful indicator in the selection of those node-negative patients with breast carcinoma who are at high risk to have occult metastasis at presentation [2], and was an commonly used important technique to quantify angiogenesis in other solid tumours [3]. The majority of published studies have shown a positive correlation between intratumoral MVD and prognosis in solid tumours [4], but not all studies have demonstrated such association, and this may be attributed to the significant differences in sample collection, immunostaining techniques, vessel counting and
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