Abstract
Cancer treatment remains a serious problem worldwide. Analysis of the relationship between cancer cells and normal cells reveals that these two share characteristics in contradiction, thus could be analyzed by using contradictory principles. Under the theory of contradictory principles, induction of a dormant state or reversal of cancer cells is an important treatment strategy beyond traditional cytotoxic therapy. Normal cells are also the targets and under the influence of anti-cancer treatments and should be considered during therapy. Findings based on crosstalk between these two cell types may offer opportunities for the development of new biomarkers and therapies.
Highlights
Developing effective anti-cancer therapy is a worldwide challenge
One possible mechanism underlying this effect may be that the short RNA fragments in the exosomes affect gene expression in normal cells. These findings suggest that the first clonal proliferation of cancer cells may induce the transformation of surrounding normal cells into cancerous cells at different stages of development
These results indicate that normal cells in the tumor microenvironment are involved in inducing tumor cell metastasis and resistance to chemotherapy
Summary
Developing effective anti-cancer therapy is a worldwide challenge. Cancer cells have often been the sole focus of studies investigating anti-cancer treatments. Under the theory of contradictory principles, induction of a dormant state or reversal of cancer cells is an important treatment strategy beyond traditional cytotoxic therapy. Normal cells are the targets and under the influence of anti-cancer treatments and should be considered during therapy.
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