Abstract
Continuous separation of pantoprazole enantiomers by biphasic recognition chiral extraction (BRCE) in a cascade of centrifugal contactor separators was studied. The BRCE system consists of isobutyl d-tartrate (d-IBTA) in the organic phase and hydrophilic-β-cyclodextrin (HP-β-CD) in the aqueous phase. The effect of W/O ratio, extractant d-IBTA concentration, and number of stages on the purity and yield of the product was investigated. A higher d-IBTA concentration and a smaller W/O ratio result in a higher purity in the raffinate phase and lower in the extract phase. More stages are required to obtain higher purities in both product streams. The desired enantiomer can be obtained by asymmetric separation, i.e., by varying the phase ratio, without the need of increasing the number of stages. The optimal conditions for symmetric separation involves a W/O ratio of 5 and 0.1 mol/L d-IBTA, which can make the eeeq up to 48% and Yeq to 68%. The technology is potentially applicable to scale production.
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