Continuous Production of Tablet Granulations in a Fluidized Bed II: Operation and Performance of Equipment

Abstract

Data collected from batch runs in a 1-ft. diameter fluidized bed granulator were employed in preliminary evaluation of process performance. Moisture content, granule screen analysis, and compressibility tests were used to evaluate the granulated product. Process variables such as powder and liquid feed rates, inlet air temperature, and nozzle location influenced the characteristics of the product. Losses from the unit were related to cyclone collector efficiency. Data obtained from replicate continuous runs under selected operating conditions illustrated the ability of the process to maintain product uniformity from run to run. Finished granulations from the continuous runs were evaluated on a rotary press. Tablets made from these granulations conformed to tablets made from identical ingredients granulated by conventional techniques. Data collected from batch runs in a 1-ft. diameter fluidized bed granulator were employed in preliminary evaluation of process performance. Moisture content, granule screen analysis, and compressibility tests were used to evaluate the granulated product. Process variables such as powder and liquid feed rates, inlet air temperature, and nozzle location influenced the characteristics of the product. Losses from the unit were related to cyclone collector efficiency. Data obtained from replicate continuous runs under selected operating conditions illustrated the ability of the process to maintain product uniformity from run to run. Finished granulations from the continuous runs were evaluated on a rotary press. Tablets made from these granulations conformed to tablets made from identical ingredients granulated by conventional techniques.