Abstract
The synthesis of non-histone chromosomal proteins in synchronized HeLa S 3 cells was studied in 3 phases of the cell cycle: S, G 2 and mitosis. A 70–90% decrease in the rate of synthesis of total cellular protein and of chromatin-associated protein fractions extractable with low salt concentrations or with dilute acid was observed in cells in mitosis. On the contrary, the residual non-histone chromosomal proteins were synthesized during mitosis at a rate which did not differ significantly from that of S and G 2 phases. Thus, at variance with the other cellular proteins, acidic chromosomal proteins are synthesized at an undiminished rate even during mitosis, when there is complete cessation of RNA synthesis.
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