Contemporary Development in Floating Oral In-Situ Gel: A Review

Abstract

Conventional oral dosage forms having low bioavailability problems due to their rapid gastric transition from stomach, in case of drugs which are less soluble at alkaline pH of intestine. Further drugs which produce their nearby activity in stomach, get quickly emptied don't get enough residence time in stomach. To avoid these problems, different endeavors have been made to draw out the the retention time of drug in stomach. The development of in situ gel systems has gotten impressive consideration in the course of recent years as it gives the most ideal approach to conquer problems of immediate release and short GI residence of fluids. In situ gel forming drug delivery systems are principle, capable of releasing drug in a sustained manner maintaining relatively constant plasma profiles. The in situ gel dosage form is a liquid before administration and after it interacts with gastric contents gets changed over to gel which floats on gastric contents. In situ gel formation happens because of one or combination of various stimuli like pH change, temperature modulation and ionic crosslinking. This accomplishes expanded residence as well as sustained release. It can be easily applied to the site of drug absorption where they swell to form a strong gel that is capable of prolonging the residence time of the active substance. This review gives a short thought regarding floating oral in situ gel formation and research done by different researchers on various drugs.