Abstract

The cytoskeleton is a network of interlinked filaments inside the cell. It plays a crucial role in maintaining the cellular shape and drives vital processes such as cell division and motility. An array of sophisticated methods exists at the scientists' disposal (such as atomic force microscopy, micropipette aspiration and optical tweezers) to exert forces on cells and investigate their mechanics. However, these methods come with fundamental drawbacks. Firstly, the necessity of direct contact between the sample and the probe potentially introduces artifacts. Secondly, they are often limited to a single cell per measurement. It would therefore be desirable to have a robust and fast technique to characterize the biomechanics of the cytoskeleton inside living cells.

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