Abstract
Effects of dietary tancy ragwort ( Senecio jacobaea), comfrey ( Symphytum officinale), bracken ( Pteridium aquilinum) and alfalfa ( Medicago saliva) on hepatic drug-metabolizing enzymes in rats were measured. Tansy ragwort and bracken increased ( P < 0.05) the activity of glutathione transferase and epoxide hydrolase. Comfrey and alfalfa increased ( P < 0.05) the activity of aminopyrine N-demethylase. Feeding bracken or St. John's wort ( Hypericum perforatum) in conjunction with tansy ragwort did not influence chronic toxicity of tansy ragwort as assessed by rat survival time. Dietary tansy ragwort resulted in increased ( P < 0.05) hepatic copper levels; the other plants did not affect copper levels. The results do not suggest any major interaction in the toxicity of tansy ragwort with bracken or St. John's wort.
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