Abstract
In this paper, a new quantitative detection system for thyroxine (T4) and carbamazepine (CBZ) was constructed. A mixture of MPA-capped Mn and ZnS quantum dots (MPA-Mn:ZnS QDs) exhibiting room-temperature phosphorescence (RTP) was prepared, which serves as the detection signal. The hexadecyltrimethylammonium bromide/ MPA-Mn:ZnS QDs (CTAB/QD) compound binds T4 to produce a CTAB/QDs&T4 complex, which results in phosphorescent quenching of the quantum dots. By adding CBZ to CTAB/QDs&T4, the phosphorescent quenching remains, allowing the quantitative detection of T4 and CBZ. Under the best experimental conditions, the linear relationship of QDs/CTAB-T4 is T4△RTP=0.4137CT4+0.1034, the correlation coefficient is R2=0.999, the detection limit is 1.95 nmol/L, and the detection range is 4.85 nmol/L to 1.59 μmol/L; the linear relationship of CTAB/QDs&T4CBZ is CBZ△RTP=0.4178x+0.112, the correlation coefficient is R2=0.995, the detection limit is 3.43 nmol/L and the detection range is 7.9 nmol/L to 1.555 μmol/L. This method has many advantages, such as anti-interference (which can overcome the autofluorescence interference of biological samples), nontoxicity, sensitivity, simple operation and low cost, and can be applied to the quantitative detection of T4 and CBZ in human serum samples.
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