Abstract
Major genitourinary anomalies have been observed in both man and laboratory animals. Kissane has estimated that approximately 10% of humans are born with a potentially significant malformation of the urinary system [1]. Urinary tract malformations were the cause of end-stage renal failure in 22% of children under the age of 5 receiving renal transplants and in 6% of transplant recipients between the ages of 6 and 15 years [2]. Hydronephrosis in animals has been noted periodically. Two reports have described strains of rats with unilateral right hydronephrosis [3, 4], whereas others have reported variably right- or left-sided unilateral hydronephrosis or bilateral hydronephrosis. Warner [5] and Lozzio, Buonocore, and Kentera [6] reported elevated BUN concentrations in hydronephrotic animals. Detailed studies of the physiologic alterations in a colony of animals with congenital hydronephrosis have not been reported. We have developed a colony of albino rats with congenital, physiologically significant, persistant, unilateral hydronephrosis suitable for such studies. The lesion in this colony has been stable over several generations of breeding.
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