Abstract
A survey of 27 newborn and older infants affected by the severe and generalized form of congenital toxoplasmosis revealed the presence of serum M-components of the IgG class in 11 cases. These immunoglobulins, of limited heterogeneity appeared to be synthesized by the fetus as they could be detected up to the seventy-fifth postpartum day and were absent in maternal serum. No antitoxoplasma antibody activity could be assigned to the M-components. During physiologic immaturity of the immune system, the expression of antigenic stimulation is limited by the pool of reactive cells and can lead to proliferation and immunoglobulin synthesis of a limited number of clones. In this respect, it parallels the description of restriction in heterogeneity of the immunoglobulins in some genetically determined or acquired states of immunodeficiency.
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