Abstract
This study evaluated the accuracy of postnatal computed tomography (CT) imaging in the identification of congenital bronchopulmonary malformation (BPM) in comparison with histopathological analysis. CT scans of prenatally diagnosed BPMs from 24 patients with available histology were analysed retrospectively. The CT images were reviewed blinded to histological findings by two radiologists. Specific diagnosis was assigned based on predetermined criteria. The accuracy of CT was evaluated. The agreement rate in CT diagnosis between two radiologists was 100%. In 75% the lesions were located in the lower lobes. An overlap of 71% in CT and histopathological diagnoses was reached. The least matching diagnosis was type 2 CPAM. Contrast enhanced chest CT is very accurate in characterizing the BPM spectrum and provides important information on lesion type and structure.
Highlights
Bronchopulmonary malformations refer to a spectrum of pulmonary developmental anomalies, including congenital pulmonary airway malformation (CPAM), previously known as congenital cystic adenomatoid malformation (CCAM), bronchopulmonary sequestration (BPS), hybrid lesion and congenital lung overinflation (CLO)
In patients with clinical suspicion of bronchopulmonary malformation (BPM), a chest computed tomography (CT) is required for the confirmation of diagnosis and further characterization of the lesion[6]
We identified 24 patients referred to our institution between the years 2010 and 2015 with a prenatal ultrasound diagnosis of BPM who had undergone surgical resection
Summary
Bronchopulmonary malformations refer to a spectrum of pulmonary developmental anomalies, including congenital pulmonary airway malformation (CPAM), previously known as congenital cystic adenomatoid malformation (CCAM), bronchopulmonary sequestration (BPS), hybrid lesion and congenital lung overinflation (CLO). These anomalies consist of about 90% of those seen in clinical practise[1]. In utero airway maldevelopment with resultant obstruction is a recurrent proposed aetiology for many of these lesions, especially those associated with hyperlucent or cystic lung changes[2] This causes even more confusion in terms of how these malformations should be described[3]. Contrast enhanced chest CT is very accurate in characterizing the BPM spectrum and provides important information on lesion type and structure
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